Recombinant SARS-Cov-2 Papain-Like Protease, His
重组SARS-CoV-2 (2019-nCoV) Papain-Like Protease
| 英文名称 | Recombinant SARS-Cov-2 Papain-Like Protease, His |
| 中文名称 | 重组SARS-CoV-2 (2019-nCoV) Papain-Like Protease |
| 别 名 | Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a; Recombinant SARS-Cov-2 Papain-Like Protease, His 新冠病毒PLpro; 新冠PLpro; SARS-CoV-2 PLpro; |
| 理论分子量 | 35.8kDa |
| 检测分子量 | 26 kDa |
| 性 状 | Liquid |
| 浓 度 | ＞0.5 mg/ml |
| 物 种 | SARS-Cov-2 |
| 序 列 | 1564-1880/7096 |
| 纯 度 | >90% as determined by SDS-PAGE |
| 纯化方法 | AC |
| 内毒素 | Not analyzed |
| 表达系统 | E.coli |
| 活性 | Not tested |
| 标签 | His |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 | Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons |
本产品仅供科研使用.请勿用于医药,不能用于临床治疗诊断使用！