Recombinant human RIPK1 protein, N-His
重组丝氨酸苏氨酸激酶1受体相互作用蛋白
| 英文名称 | Recombinant human RIPK1 protein, N-His |
| 中文名称 | 重组丝氨酸苏氨酸激酶1受体相互作用蛋白 |
| 别 名 | Cell death protein RIP; Receptor (TNFRSF) interacting serine threonine kinase 1; Receptor interacting protein; Receptor interacting serine threonine protein kinase 1; Receptor TNFRSF interacting serine threonine kinase 1; Receptor-interacting protein 1; Receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP; Rip-1; RIPK 1; RIPK-1; RIPK1_HUMAN; Serine threonine protein kinase RIP; Serine/threonine-protein kinase RIP. |
| 理论分子量 | 28.7kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | >1mg/ml |
| 物 种 | Human |
| 纯 度 | >90% as determined by SDS-PAGE |
| 内毒素 | Not analyzed |
| 表达系统 | E.coli |
| 活性 | Not tested |
| 标签 | C-His |
| 缓 冲 液 | 20mM Tris (pH=8.0) with 8M Urea |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 | Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains. |
| 产品图片 |
 The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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本产品仅供科研使用.请勿用于医药,不能用于临床治疗诊断使用！