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上海信裕生物科技有限公司
LNPEP抗体

LNPEP抗体

商家询价

产品名称： LNPEP抗体

英文名称： LNPEPAntibody

产品编号： XYXY559Hu22 丝切蛋白1(CFL1)单克隆抗体

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 LNPEP抗体

Applications
In-house applications ELISA, WB, IHC     Application not tested? Please see our Guarantee.
Species specificity Human; other species not tested.
Images
Prev1NextView more validation data
  • 55154-1-AP;human brain tissuehuman brain tissue were subjected to SDS PAGE followed by western blot with 55154-1-AP(LNPEP antibody) at dilution of 1:800
  • 55154-1-AP;human heartImmunohistochemical of paraffin-embedded human heart using 55154-1-AP(LNPEP antibody) at dilution of 1:50 (under 10x lens)
  • 55154-1-AP;human heartImmunohistochemical of paraffin-embedded human heart using 55154-1-AP(LNPEP antibody) at dilution of 1:50 (under 40x lens)
Positive WB detected in Human brain tissue, COLO 320 cells, human heart tissue
Positive IHC detected in Human heart tissue, human kidney tissue
Recommended dilution WB : 1:200-1:2000
IHC : 1:20-1:200
 LNPEP抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen Peptide Full name Leucyl/cystinyl aminopeptidase
Calculated molecular
weight		 117 kDa Observed molecular 
weight		 117-125 kDa
GenBank accession 
number		 NM_005575 Gene ID (NCBI) 4012
Gene symbol LNPEP Synonyms CAP, Cystinyl aminopeptidase, IRAP, Leucyl cystinyl aminopeptidase, leucyl/cystinyl aminopeptidase, LNPEP, OTase, Oxytocinase, P LAP, PLAP, VP165
Background LNPEP抗体

LNPEP, also named as OTASE, IRAP, P-LAP and Otase, belongs to the peptidase M1 family. It may be involved in the inactivation of neuronal peptides in the brain. LNPEP cleaves Met-enkephalin and dynorphin. It binds angiotensin IV and may be the angiotensin IV receptor in the brain. It can be detected a protein with molecular mass of 165 kDa in several human tissues including heart, small intestine, kidney and 140 kDa in brain. LNPEP contains 18 potential N-glycosylation sites so that the differential usage of the glycosylation site in the brain causes the difference in the molecular mass of the enzyme.(PMID:11389728). Two forms of LNPEP are purified from human placenta: one is a monomeric, 61-kDa protein and the other is a heterodimeric protein with 64- and 97-kDa subunits(PMID:10601849). It can form a homodimer of 280 kDa(PMID:10601849). This antibody is specific to LNPEP. LNPEP抗体

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