Monoclonal Antibody against Ubiquitin (3-39)
产品名称: Monoclonal Antibody against Ubiquitin (3-39)
英文名称: Monoclonal Antibody against Ubiquitin (3-39)
产品编号: SIG-39500
产品价格: null
产品产地: USA
品牌商标: COVANCE
更新时间: 2023-08-17T13:40:59
使用范围:
翌圣生物科技(上海)股份有限公司
- 联系人 : 李自转
- 地址 : 上海市浦东新区天雄路166弄一号楼三层南单元
- 邮编 : 200030
- 所在区域 : 上海
- 电话 : 139****5640 点击查看
- 传真 : 点击查看
- 邮箱 : lizizhuan@yeasen.com
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Description | Monoclonal Antibody against Ubiquitin (3-39) (Formerly Signet Catalog Nos: 9500-02, 9500-05, 9500-10) | |
Intended Use | **Research Use Only (RUO)** This product is sold for laboratory research use only, not for human or in-vivo use. | |
Clone | 3-39 | |
Form | Ascites | |
Host | Mouse | |
IsoType | IgG1, kappa | |
[Ab] | ~2 mg/mL | |
Specificity | This antibody detects ubiquitinated proteins. It is specific for residues 50-65 of ubiquitin and recognizes ubiquitinated protein, but not free ubiquitin. Clone 3-39 can be used on native or detergent extracted formalin fixed tissues and the epitope is resistant to proteolytic enzyme treatment. | |
Uses | This antibody is effective in immunoblotting, immunohistochemistry (IHC) on unfixed tissues, immunoprecipitation (IP) and ELISA. | |
Suggested Working Dilution | The optimal working dilution should be determined for each specific assay condition.
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Storage | Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers. | |
References | Wang GP, Khatoon S, Iqbal K, Grundke-Iqbal I. Brain ubiquitin is markedly elevated in Alzheimer’s disease. Brain Res 566:146- 151, 1991. Wang GP, Iqbal K, Bucht G, Winblad B, Wisniewski HM, Grundke- Iqbal I. Alzheimer’s disease: paired helical filament immunoreactivity in cerebrospinal fluid. Acta Neuropathol 82:6-12, 1991. Perry G, Mulvhill P, Fried VA, Smith HT, Grundke-Iqbal I, Iqbal K. Immunochemical properties of ubiquitin conjugated in the paired helical filaments of Alzheimer’s disease. J Neurochem 52:1523- 1528, 1989. Galloway PG, Grundke-Iqbal I, Iqbal K, Perry G. Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles. J Neuropath Exper Neurol 47:654-663, 1988. Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi M, Wisniewski HM. Microtubule-associated protein tau, a component of Alzheimer paired helical filaments. J Biol Chem 261:6084-6089, 1986. Grundke-Iqbal I, Wang GP, Iqbal K, Tung YC, Wisniewski HM. Alzheimer paired helical filaments: Identification of polypeptides with monoclonal antibodies. Acta Neuropathol 68:279-283, 1985. Wang GP, Grundke-Iqbal, Kascsak RJ, Iqbal K, Wisniewski HM. Alzheimer neurofibrillary tangles: Monoclonal antibodies to inherent antigen(s). Acta Neuropathol 62:268-275, 1984. | |
Warranty/Conditions | Covance products may not be resold or modified for resale without prior written approval. | |
Rev. Date | 4/8/2007 |