Anti-Notch1 mAb: ATTO 633 [S253-32]-抗体-抗体-生物在线
StressMarq
Anti-Notch1 mAb: ATTO 633 [S253-32]

Anti-Notch1 mAb: ATTO 633 [S253-32]

商家询价

产品名称: Anti-Notch1 mAb: ATTO 633 [S253-32]

英文名称: Notch1 Monoclonal Antibody: ATTO 633 [S253-32]

产品编号: SMC-430D-A633

产品价格: null

产品产地: 加拿大

品牌商标: StressMarq

更新时间: null

使用范围: WB, ICC

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Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.