Product: Anti-Desmoglein 3, clone 5G11
Cat. No.: MC-214 (1 mL)
Description:
Desmoglein 3 is a member of the desmosomal
cadherin family that comprise the desmogleins
and desmocollins. Desmosomes are cell-cell
junctions in most epithelial cells and serve to link
the intermediate filament cytoskeletons of
adjacent cells. Within the desmosome the
extracellular domain of desmoglein is essential
for calcium dependent heterophilic binding to the
desmocollins, whereas the intracellular domain
is essential for binding to the desmosomal
plaque protein, plakoglobin. Desmoglein 3 is
synthesized in both the basal and the lower
suprabasal compartments.
Specificity:
Reacts with the 140 kDa desmoglein 3 protein.
Does not cross-react with desmoglein 1 or
desmoglein 2. The antibody does not inhibit
biological activity of desmoglein 3.
Isotype:
Mouse IgG1
Species Reactivity:
Human. Others not tested.
Format:
1 mL at 100 μg/mL of 0.2 μm filtered antibody
solution in PBS containing 0.1% protein
stabilizer and 0.02% sodium azide.
Storage:
Store at 4°C.
Applications:

Immunofluorescence: Use at a 1:10 dilution

Immunohistochemistry (paraffin embedded
sections)

Immunoprecipitation

Western blot: Use at a 1:10 dilution
The optimal dilution for a specific application
should be determined by the researcher.
Limitations:
For in vitro research use only. Not for use in
diagnostics or in humans.
Warranty:
No warranties, expressed or implied, are made
regarding the use of this product. KAMIYA
BIOMEDICAL COMPANY is not liable for any
damage, personal injury, or economic loss
caused by this product.