1) Cat. No.: TRC-P571500; 2) Chemical Name: PK 11195; 3) CAS No.: 85532-75-8; 4) Mol. Formula: C21H21ClN2O; 5) Mol. Weight: 352.86; 6) Packing Size: 25mg / 50mg; 7) Appearence: ; 8) Application Notes: PK 11195 is a high affinity peripheral benzodiazepine receptor (PBR) ligand. PK 11195 has been shown to regulate protein phosphorylation in rat brain mitochondria under control of Ca2+. PK11195 promotes mitochondrial apoptosis and blocks P-glycoprotein (Pgp)-mediated drug efflux to chemosensitize cancer cells.; 9) Synonym: 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide; N-Methyl-N-(1-methylpropyl)-1-(2-chlorophenyl)isoquinoline-3-carboxamide; RP 52028;; 10) Solubility: ; 11) Storage condition: ; 12) References: Azarashvili, T. et al.: J. Neurochem., 94, 1054 (2005); Le Fur, G. et al.: Life Sci., 33, 449 (1983); Walter, R.B. et al.: